DISEASES

Disease-gene associations mined from literature

Literature on L3MBTL2

L3MBTL2 [ENSP00000216237]

Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'; MBT domain containing

Synonyms:  L3MBTL2,  L3MBTL2p,  hL3MBTL2,  F8WBL1,  H7C228 ...

Linkouts:  STRING  Pharos  UniProt  OMIM