DISEASES

Disease-gene associations mined from literature

Literature on MAPK8IP2

MAPK8IP2 [ENSP00000330572]

Mitogen-activated protein kinase 8 interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Synonyms:  MAPK8IP2,  A8MTJ1,  J3KNN6,  MAPK8IP2-001,  MAPK8IP2-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM