DISEASES

Disease-gene associations mined from literature

Literature on GNA13

GNA13 [ENSP00000400717]

Guanine nucleotide binding protein (G protein), alpha 13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation; Belongs to the G-alpha family. G(12) subfamily.

Synonyms:  GNA13,  GNA13p,  hGNA13,  A0A024R8M0,  Q14344 ...

Linkouts:  STRING  Pharos