DISEASES

Disease-gene associations mined from literature

Literature on DEFB1

DEFB1 [ENSP00000297439]

Defensin, beta 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family.

Synonyms:  DEFB1,  DEFB1p,  hDEFB1,  P60022,  BD1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM