DISEASES

Disease-gene associations mined from literature

Literature on IL23A

IL23A [ENSP00000228534]

Interleukin 23, alpha subunit p19; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis; Interleukins

Synonyms:  IL23Ap,  hIL23A,  IL23A-001,  IL23A-002,  IL23A-003 ...

Linkouts:  STRING  Pharos  UniProt  OMIM