DISEASES

Disease-gene associations mined from literature

Literature on CDT1

CDT1 [ENSP00000301019]

Chromatin licensing and DNA replication factor 1; Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre- RC). Required also for mitose by promoting stable kinetochore-microtubule attachments. Potential oncogene (By similarity); Belongs to the Cdt1 family.

Synonyms:  CDT1,  CDT1p,  hCDT1,  Q9H211,  Q9H211p ...

Linkouts:  STRING  Pharos  UniProt  OMIM