DISEASES

Disease-gene associations mined from literature

Literature on TRAF4

TRAF4 [ENSP00000262395]

Cysteine-rich domain associated with RING and Traf domains protein 1; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.

Synonyms:  TRAF4,  TRAF4p,  hTRAF4,  A0A024QZ19,  A0A024QZ59 ...

Linkouts:  STRING  Pharos  UniProt  OMIM