DISEASES

Disease-gene associations mined from literature

Literature on PARVA

PARVA [ENSP00000334008]

Calponin-like integrin-linked kinase-binding protein; Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration; Belongs to the parvin family.

Synonyms:  PARVA,  E9PS97,  J3KNQ4,  Q9NVD7,  E9PS97p ...

Linkouts:  STRING  Pharos  UniProt  OMIM