DISEASES

Disease-gene associations mined from literature

Literature associating HIST1H3B and brain stem glioma

HIST1H3B [ENSP00000484841]

Histone cluster 1, H3b; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST1H3B,  HIST1H3A,  H3FA,  H3FB,  H3FC ...

Linkouts:  STRING  Pharos