Literature associating ACACA and metabolic dysfunction-associated steatohepatitis
ACACA [ENSP00000483300]
Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis . This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443).
Synonyms: ACACA, A0A024R0Y2, A0A087WVR6, A0A087WWN5, A0A087WYK6 ...