DISEASES

Disease-gene associations mined from literature

Literature associating CCL4 and bone disease

CCL4 [ENSP00000482259]

Macrophage inflammatory protein 1-beta; Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B; Belongs to the intercrine beta (chemokine CC) family.

Synonyms:  CCL4,  CCL4p,  hCCL4,  LAG1,  MIP1B ...

Linkouts:  STRING  Pharos