DISEASES

Disease-gene associations mined from literature

Literature associating DACH1 and branchiootorenal syndrome

DACH1 [ENSP00000482245]

Dachshund family transcription factor 1; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Synonyms:  DACH1,  DACH1p,  hDACH1,  Q9UI36,  DACH ...

Linkouts:  STRING  Pharos  UniProt