DISEASES

Disease-gene associations mined from literature

Literature associating SOCS2 and essential thrombocythemia

SOCS2 [ENSP00000481249]

Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; SH2 domain containing

Synonyms:  SOCS2,  SOCS2p,  hSOCS2,  A0A024RBD2,  B4DMW5 ...

Linkouts:  STRING  Pharos  UniProt