DISEASES

Disease-gene associations mined from literature

Literature associating MGAT4C and Walker-Warburg syndrome

MGAT4C [ENSP00000481096]

UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity); Mannosyl-glycoprotein N-acetylglucosaminyltransferases

Synonyms:  MGAT4C,  MGAT4Cp,  hMGAT4C,  B4DRH2,  F8VTY5 ...

Linkouts:  STRING  Pharos  UniProt