DISEASES

Disease-gene associations mined from literature

Literature associating MCM3 and balanitis xerotica obliterans

MCM3 [ENSP00000480987]

DNA polymerase alpha holoenzyme-associated protein P1; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Synonyms:  MCM3,  MCM3p,  hMCM3,  B4DWW4,  HCC5 ...

Linkouts:  STRING  Pharos  UniProt