DISEASES

Disease-gene associations mined from literature

Literature associating HIST1H3A and brain stem glioma

HIST1H3A [ENSP00000480826]

Histone cluster 1, H3a; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST1H3A,  V9H1G0,  V9H1G0p,  hV9H1G0,  1CS9 ...

Linkouts:  STRING  Pharos