Disease-gene associations mined from literature

Literature associating NUDT18 and atrial heart septal defect 3

NUDT18 [ENSP00000480722]

Nudix (nucleoside diphosphate linked moiety X)-type motif 18; Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools; Belongs to the Nudix hydrolase family.

Synonyms:  NUDT18,  NUDT18p,  hNUDT18,  E5RJJ3,  Q6ZVK8 ...

Linkouts:  STRING  Pharos  UniProt