DISEASES

Disease-gene associations mined from literature

Literature associating HIST1H4A and familial hyperinsulinemic hypoglycemia 1

HIST1H4A [ENSP00000479106]

Histone cluster 1, H4a; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST1H4A,  B2R4R0,  Q6B823,  B2R4R0p,  hB2R4R0 ...

Linkouts:  STRING  Pharos