DISEASES

Disease-gene associations mined from literature

Literature associating GREM1 and large intestine lipoma

GREM1 [ENSP00000478319]

Down-regulated in Mos-transformed cells protein; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity); Belongs to the DAN family.

Synonyms:  GREM1,  GREM1p,  hGREM1,  H0YLY2,  CKTSF1B1 ...

Linkouts:  STRING  Pharos