Literature associating HIST2H2AA3 and systemic scleroderma
Histone cluster 2, H2aa4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Synonyms: HIST2H2AA3, HIST2H2AA4, H2AFO, HIST2H2AA, 723790 ...