DISEASES

Disease-gene associations mined from literature

Literature associating NELFCD and Pancoast tumor

NELFCD [ENSP00000473290]

Negative elongation factor complex member C/D; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure- dependent manner; Belongs to the NELF-D family.

Synonyms:  NELFCD,  H0UI80,  Q8IXH7,  TH1L,  TH1L-001 ...

Linkouts:  STRING  Pharos  UniProt