Literature associating SPIB and primary biliary cholangitis
Spi-B transcription factor (Spi-1/PU.1 related); Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation; ETS transcription factor family
Synonyms: SPIB, A0A024R4I5, M0QXA8, M0R037, M0R2J9 ...