DISEASES

Disease-gene associations mined from literature

Literature associating DYRK1B and liver rhabdomyosarcoma

DYRK1B [ENSP00000469863]

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Synonyms:  DYRK1B,  DYRK1Bp,  hDYRK1B,  A0A024R0I0,  A0A024R0J6 ...

Linkouts:  STRING  Pharos  UniProt