DISEASES

Disease-gene associations mined from literature

Literature associating WBP2 and Renpenning syndrome

WBP2 [ENSP00000467579]

WW domain binding protein 2; Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1- responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity); GRAM domain containing

Synonyms:  WBP2,  WBP2p,  hWBP2,  A0A024R8L1,  A6NG10 ...

Linkouts:  STRING  Pharos  UniProt