DISEASES

Disease-gene associations mined from literature

Literature associating RNF213 and cerebral atherosclerosis

RNF213 [ENSP00000464087]

ALK lymphoma oligomerization partner on chromosome 17; E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity; Ring finger proteins

Synonyms:  RNF213,  RNF213p,  hRNF213,  H3BLU6,  Q63HN8 ...

Linkouts:  STRING  Pharos  UniProt