DISEASES

Disease-gene associations mined from literature

Literature associating RNF115 and Charcot-Marie-Tooth disease type 2B

RNF115 [ENSP00000463650]

RING-type E3 ubiquitin transferase RNF115; E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4; Ring finger proteins

Synonyms:  RNF115,  RNF115p,  hRNF115,  Q9Y4L5,  Q9Y4L5p ...

Linkouts:  STRING  Pharos  UniProt