DISEASES

Disease-gene associations mined from literature

Literature associating CARD14 and pustulosis of palm and sole

CARD14 [ENSP00000458715]

Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14- induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis; Caspase recruitment domain containing

Synonyms:  CARD14,  CARD14p,  hCARD14,  E7ETJ2,  I3L1Z7 ...

Linkouts:  STRING  Pharos  UniProt