Literature associating MMP12 and chronic obstructive pulmonary disease
Matrix metallopeptidase 12 (macrophage elastase); May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3; Belongs to the peptidase M10A family.
Synonyms: MMP12, MMP12p, hMMP12, P39900, HME ...