Literature associating METTL4 and chromosome 18p deletion syndrome
METTL4 [ENSP00000458290]
N(6)-adenine-specific DNA methyltransferase METTL4; N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) and is required to regulate Polycomb silencing. N(6)- methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing; Belongs to the MT-A70-like family.
Synonyms: METTL4, METTL4p, hMETTL4, I3L0Y1, I3L3W2 ...