DISEASES

Disease-gene associations mined from literature

Literature associating SLC25A24 and Sengers syndrome

SLC25A24 [ENSP00000457733]

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24; Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.

Synonyms:  SLC25A24,  H3BMI3,  J3KN42,  Q6NUK1,  SLC25A24-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM