Disease-gene associations mined from literature

Literature associating WWOX and peripheral osteosarcoma

WWOX [ENSP00000457230]

Short chain dehydrogenase/reductase family 41C member 1; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm; Short chain dehydrogenase/reductase superfamily

Synonyms:  WWOX,  F5H3R5,  H3BMD1,  Q9NZC7,  F5H3R5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM