Literature associating ARPP19 and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression; Belongs to the endosulfine family.
Synonyms: ARPP19, ARPP19p, hARPP19, A0A024R5U3, ARPP-19 ...