Disease-gene associations mined from literature

Literature associating TRAF3 and splenic marginal zone lymphoma

TRAF3 [ENSP00000454207]

RING-type E3 ubiquitin transferase TRAF3; Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14; Belongs to the TNF receptor-associated factor family. A subfamily.

Synonyms:  TRAF3,  TRAF3p,  hTRAF3,  A6NHG8,  H0YL25 ...

Linkouts:  STRING  Pharos  UniProt