Literature associating PAK6 and breast large cell neuroendocrine carcinoma
PAK6 [ENSP00000453858]
Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Synonyms: PAK6, BUB1B-PAK6, PAK6p, hPAK6, A0A024R9Q4 ...