DISEASES

Disease-gene associations mined from literature

Literature associating BUB1B-PAK6 and La Crosse encephalitis

BUB1B-PAK6 [ENSP00000453858]

P21 protein (Cdc42/Rac)-activated kinase 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Synonyms:  PAK6,  PAK6p,  hPAK6,  BUB1B-PAK6,  G5E9R2 ...

Linkouts:  STRING  Pharos  UniProt