DISEASES

Disease-gene associations mined from literature

Literature associating TLE3 and chromosome 1q21.1 duplication syndrome

TLE3 [ENSP00000452871]

Enhancer of split groucho-like protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity); WD repeat domain containing

Synonyms:  TLE3,  TLE3p,  hTLE3,  B4E2W3,  F5H7D6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM