Literature associating APAF1 and familial hemophagocytic lymphohistiocytosis 3
Apoptotic peptidase activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis; Apoptosome
Synonyms: APAF1, APAF1p, hAPAF1, C9JLV4, F8VNZ0 ...