DISEASES

Disease-gene associations mined from literature

Literature associating NLRP2 and gestational trophoblastic neoplasm

NLRP2 [ENSP00000445135]

PYRIN domain and NACHT domain-containing protein 1; Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases; NLR family

Synonyms:  NLRP2,  NLRP2p,  hNLRP2,  NLRP2-001,  NLRP2-002 ...

Linkouts:  STRING  Pharos  UniProt