DISEASES

Disease-gene associations mined from literature

Literature associating APOA5 and pancreatitis

APOA5 [ENSP00000445002]

Regeneration-associated protein 3; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.

Synonyms:  APOA5,  APOA5p,  hAPOA5,  APOA5-001,  APOA5-002 ...

Linkouts:  STRING  Pharos  UniProt