Literature associating ZNRF3 and skin melanoma
RING-type E3 ubiquitin transferase ZNRF3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone; Belongs to the ZNRF3 family.
Synonyms: ZNRF3, ZNRF3p, hZNRF3, A0A024R1J1, Q9ULT6 ...