DISEASES

Disease-gene associations mined from literature

Literature associating ZNRF3 and skin carcinoma

ZNRF3 [ENSP00000443824]

RING-type E3 ubiquitin transferase ZNRF3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone; Belongs to the ZNRF3 family.

Synonyms:  ZNRF3,  ZNRF3p,  hZNRF3,  A0A024R1J1,  Q9ULT6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM