Disease-gene associations mined from literature

Literature associating HIST4H4 and neuronal ceroid lipofuscinosis

HIST4H4 [ENSP00000443017]

Histone cluster 4, H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST4H4,  HIST4H4p,  hHIST4H4,  121504,  1ZKK ...

Linkouts:  STRING  Pharos