DISEASES

Disease-gene associations mined from literature

Literature associating JHDM3C and central nervous system cancer

JHDM3C [ENSP00000442382]

Lysine (K)-specific demethylase 4C; Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Synonyms:  KDM4C,  KDM4Cp,  hKDM4C,  Q9H3R0,  GASC1 ...

Linkouts:  STRING  Pharos  UniProt