DISEASES

Disease-gene associations mined from literature

Literature associating TOP3A and acute pericementitis

TOP3A [ENSP00000442336]

Topoisomerase (DNA) III alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity; Topoisomerases

Synonyms:  TOP3A,  TOP3Ap,  hTOP3A,  A8K398,  B4DSJ0 ...

Linkouts:  STRING  Pharos  UniProt