DISEASES

Disease-gene associations mined from literature

Literature associating PHB2 and enthesopathy

PHB2 [ENSP00000441875]

B-cell receptor-associated protein BAP37; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Synonyms:  PHB2,  PHB2p,  hPHB2,  F5GWA7,  F5GY37 ...

Linkouts:  STRING  Pharos  UniProt  OMIM