DISEASES

Disease-gene associations mined from literature

Literature associating ITGAM and chronic NK-cell lymphocytosis

ITGAM [ENSP00000441691]

Integrin, alpha M (complement component 3 receptor 3 subunit); Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).

Synonyms:  ITGAM,  B3KXM6,  I3NI33,  P11215,  B3KXM6p ...

Linkouts:  STRING  Pharos  UniProt  OMIM