Literature associating CYP2E1 and metabolic dysfunction-associated steatohepatitis
CYP2E1 [ENSP00000440689]
Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids . May be involved in the oxidative metabolism of xenobiotics (Probable).
Synonyms: CYP2E1, CYP2E1p, hCYP2E1, F5H694, H0Y593 ...