Disease-gene associations mined from literature

Literature associating PHC1 and autotopagnosia

PHC1 [ENSP00000440674]

Early development regulatory protein 1; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression; Sterile alpha motif domain containing

Synonyms:  PHC1,  PHC1p,  hPHC1,  F5GZP4,  F5H0T9 ...

Linkouts:  STRING  Pharos  UniProt