DISEASES

Disease-gene associations mined from literature

Literature associating ADM and liver cirrhosis

ADM [ENSP00000436607]

Adrenomedullin; AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels; Endogenous ligands

Synonyms:  ADM,  E9PL83,  E9PML4,  E9PQE6,  E9PQT2 ...

Linkouts:  STRING  Pharos  UniProt