DISEASES

Disease-gene associations mined from literature

Literature associating EHF and leprosy

EHF [ENSP00000435835]

Epithelium-specific Ets transcription factor 3; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

Synonyms:  EHF,  E9PN75,  E9PPS9,  E9PQR6,  E9PQX0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM